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<title>Unit of Biostatistics - Karolinska Institutet</title>
<META NAME="Keywords" CONTENT="Unit Biostatistics Software Command Publications Presentations stata programming imm karolinska imm institute environmental">

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<link rel="shortcut icon" href="http://www.imm.ki.se/biostatistics/images/header.ico" type="image/x-icon" />

<SCRIPT LANGUAGE="JavaScript">

function Calculate(){
	var A0 = document.getElementById('a0').value;
	Colon = -(A0-70)*.01010594+eval(0.22224168*document.form.b1.checked)-eval(0.1923432*document.form.b2.checked)+
		eval(0.5521866*document.form.c11.checked)+eval(1.7261174*document.form.c12.checked)+
		eval(2.3762456*document.form.c21.checked)+eval(1.4489887*document.form.c22.checked)+
		eval(0.86342356*document.form.d1.checked)+eval(1.7244769*document.form.d2.checked)+
		eval(0.35989385*document.form.f1.checked)+eval(1.1850358*document.form.f2.checked)+
		eval(0.425893*document.form.e1.checked)+eval(0.79670007*document.form.g1.checked)-
		eval(0.59209064*document.form.i1.checked)+eval(0.6886927*document.form.mt1.checked)

	Rectal = -(A0-70)*0.02967144+eval(1.317115*document.form.c1.checked)+
		eval(1.8642029*document.form.c2.checked)+
		eval(0.88299732*document.form.d1.checked)+eval(1.463878*document.form.d2.checked)+
		eval(1.3494755*document.form.f1.checked)+eval(1.4173231*document.form.f2.checked)+
		eval(.6141459*document.form.e1.checked)-eval(1.029885*document.form.h1.checked)-
		eval(0.19370735*document.form.i1.checked)

C1 = 1-Math.pow(0.9983235,Math.exp(Colon))
C2 = 1-Math.pow(0.9965575,Math.exp(Colon))
C3 = 1-Math.pow(0.9949923,Math.exp(Colon))
C5 = 1-Math.pow(0.9926302,Math.exp(Colon))
R1 = 1-Math.pow(0.9839568,Math.exp(Rectal))
R2 = 1-Math.pow(0.9699391,Math.exp(Rectal))
R3 = 1-Math.pow(0.9574039,Math.exp(Rectal))
R5 = 1-Math.pow(0.9429536,Math.exp(Rectal))

if (document.getElementById('CCid').checked){
	input = Math.round(C1*1000)
	if (input/10 == Math.round(input/10)){
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	else{
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	input = Math.round(C2*1000)
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	else{
		document.form.mC2.value=Math.round(C2*1000)/10+"%"
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	input = Math.round(C3*1000)
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	input = Math.round(R2*1000)
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		}
	else{
		document.form.mC2.value=Math.round(R2*1000)/10+"%"
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	input = Math.round(R3*1000)
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		}
	else{
		document.form.mC3.value=Math.round(R3*1000)/10+"%"
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	input = Math.round(R5*1000)
	if (input/10 == Math.round(input/10)){
		document.form.mC5.value=Math.round(R5*1000)/10+".0%"
		}
	else{
		document.form.mC5.value=Math.round(R5*1000)/10+"%"
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}

Prova = document.form.b0.checked+document.form.b1.checked+document.form.b2.checked+
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 	     document.form.mt0.checked+document.form.mt1.checked

if (Prova<1){
	document.form.mC1.value=""
	document.form.mC2.value=""
	document.form.mC3.value=""
	document.form.mR1.value=""
	document.form.mR2.value=""
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	document.getElementById("PT02b").color="Black"
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	document.form.i0.checked=true
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	Calculate()
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	Calculate()
}


</script>

<link rel=stylesheet href="http://www.imm.ki.se/biostatistics/style.css" type="text/css">

</head>

<body bgcolor="white">
<form name="form">
<center>


<table cellpadding="10" cellspacing="0" width="800" bgcolor="white"><tr>
<tr bgcolor="#f3f3f1" height="50">
<td valign="center" align="center">
<font face="verdana" size=4>
<b>Risk of metachronous peritoneal carcinomatosis<br>from colorectal cancer</b>
</font>
</table>

<br><br>

<hr width="420" color="silver">
<table cellpadding="0" cellspacing="0" width="420" bgcolor="white"><tr>
<td valign="center" align="center" width="140"><font face="verdana" size=3>1 year</td>
<td valign="center" align="center" width="140"><font face="verdana" size=3>2 years</td>
<td valign="center" align="center" width="140"><font face="verdana" size=3>3 years</td>
<tr>
<td valign="center" align="center" width="140">
<input readonly='readonly' type="text" size="4" name="mC1" value="0.4%" style='overflow:hidden; border:0px solid #000000;text-align:center; font-size:16px; width:140px;' >
</td>
<td valign="center" align="center" width="140">
<input readonly='readonly' type="text" size="4" name="mC2" value="0.8%" style='overflow:hidden; border:0px solid #000000;text-align:center;font-size:16px; width:140px;' >
</td>
<td valign="center" align="center" width="140">
<input readonly='readonly' type="text" size="4" name="mC3" value="1.1%" style='overflow:hidden; border:0px solid #000000;text-align:center;font-size:16px; width:140px;' >
</td>
</tr>
</table>
<hr width="420" color="silver">

<br>

<table cellpadding="0" cellspacing="0" width="420" bgcolor="white"><tr>
<td valign="center" align="center" width="210"><font face="verdana" size=3>
<input type="radio" name="Cancer" id="CCid" value="CC" checked onClick="ChangeC()"><font face="verdana" style="font-size:12pt" id="CC">&nbsp Colon cancer</td>
<td valign="center" align="center" width="210"><font face="verdana" size=3>
<input type="radio" name="Cancer" id="RCid" value="RC" onClick="ChangeR()"><font face="verdana" style="font-size:12pt" id="RC" >&nbsp Rectal cancer</td>
</tr>
</table>

<br>
<table cellpadding="0" cellspacing="0" width="800" bgcolor="white">
<tr bgcolor="#f3f3f1" height="50">
<td valign="center" align="left" width="300">
<font face="verdana" style="font-size:12pt" >
<p align="left">&nbsp Age</p></td>
<td valign="center" align="left" width="80">
<font face="verdana" size="4">
<input type="text" name="a0" value='70' style="font-size:12pt" size="4" id="a0" onchange="Calculate()"></td>
<td valign="center" align="center" width="420"></td>
</tr>


<table cellpadding="0" cellspacing="0" width="800" bgcolor="white">
<tr height="50">
<td valign="center" align="left" width="300">
<font face="verdana" style="font-size:12pt"  id="PS">&nbsp Primary site</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="b0" checked onClick = "document.form.b0.checked=true;document.form.b1.checked=false;document.form.b2.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt"  id="PSL">Left</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="b1" onClick = "document.form.b0.checked=false;document.form.b1.checked=true;document.form.b2.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt"  id="PSR">Right</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="b2" onClick = "document.form.b0.checked=false;document.form.b1.checked=false;document.form.b2.checked=true;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt"  id="PST">Transverse </td>
</tr>

<tr bgcolor="#f3f3f1" height="50">
<td valign="center" align="left" width="300">
<font face="verdana" style="font-size:12pt"  id="PTbis">&nbsp pT stage (colon)</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="c00" checked onClick = "document.form.c00.checked=true;document.form.c11.checked=false;document.form.c12.checked=false;document.form.c21.checked=false;document.form.c22.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt"  id="PT02b">T0-T2</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="c11" onClick = "document.form.c00.checked=false;document.form.c11.checked=true;document.form.c12.checked=false;document.form.c21.checked=false;document.form.c22.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt"  id="PT3a">T3a/b</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="c12" onClick = "document.form.c00.checked=false;document.form.c11.checked=false;document.form.c12.checked=true;document.form.c21.checked=false;document.form.c22.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt"  id="PT3c">T3c/d</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="c21" onClick = "document.form.c00.checked=false;document.form.c11.checked=false;document.form.c12.checked=false;document.form.c21.checked=true;document.form.c22.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt"  id="PT4a">T4a</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="c22" onClick = "document.form.c00.checked=false;document.form.c11.checked=false;document.form.c12.checked=false;document.form.c21.checked=false;document.form.c22.checked=true;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt"  id="PT4b">T4b</td>
</tr>

<tr height="50">
<td valign="center" align="left" width="300">
<font face="verdana" font color="Gray" style="font-size:12pt"  id="PT">&nbsp pT stage (rectal)</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="c0" disabled="true" onClick = "document.form.c0.checked=true;document.form.c1.checked=false;document.form.c2.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" font color="Gray" style="font-size:12pt"  id="PT02">T0-T2</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="c1" disabled="true" onClick = "document.form.c0.checked=false;document.form.c1.checked=true;document.form.c2.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" font color="Gray" style="font-size:12pt"  id="PT3">T3</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="c2" disabled="true" onClick = "document.form.c0.checked=false;document.form.c1.checked=false;document.form.c2.checked=true;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" font color="Gray" style="font-size:12pt"  id="PT4">T4</td>
<td width="20"> </td>
<td width="80"> </td>
<td width="20"> </td>
<td width="80"> </td>
</tr>

<tr bgcolor="#f3f3f1" height="50">
<td valign="center" align="left" width="300">
<font face="verdana" style="font-size:12pt" >&nbsp pN stage</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="d0" checked onClick = "document.form.d0.checked=true;document.form.d1.checked=false;document.form.d2.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt" >N0</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="d1" onClick = "document.form.d0.checked=false;document.form.d1.checked=true;document.form.d2.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt" >N1</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="d2" onClick = "document.form.d0.checked=false;document.form.d1.checked=false;document.form.d2.checked=true;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt" >N2</td>
<td width="20"> </td>
<td width="80"> </td>
<td width="20"> </td>
<td width="80"> </td>
</tr>

<tr height="50">
<td valign="center" align="left" width="300">
<font face="verdana" style="font-size:12pt" >&nbsp Radicality</a></td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="f0" checked onClick = "document.form.f0.checked=true;document.form.f1.checked=false;document.form.f2.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt" >R0</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="f1" onClick = "document.form.f0.checked=false;document.form.f1.checked=true;document.form.f2.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt" >R1</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="f2" onClick = "document.form.f0.checked=false;document.form.f1.checked=false;document.form.f2.checked=true;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt" >R2</td>
<td width="20"> </td>
<td width="80"> </td>
<td width="20"> </td>
<td width="80"> </td>
</tr>

<tr bgcolor="#f3f3f1" height="50">
<td valign="center" align="left" width="300">
<font face="verdana" style="font-size:12pt"  id="TS">&nbsp Type of surgery</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="g0" checked onClick = "document.form.g0.checked=true;document.form.g1.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt"  id="TSEl">Elective</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="g1" onClick = "document.form.g0.checked=false;document.form.g1.checked=true;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt"  id="TSEm">Emergency</td>
<td valign="center" align="right" width="20"></td>
<td valign="center" align="center" width="80"></td>
<td width="20"> </td>
<td width="80"> </td>
<td width="20"> </td>
<td width="80"> </td>
</tr>

<tr height="50">
<td valign="center" align="left" width="300">
<font face="verdana" font color="Gray" id="PR" style="font-size:12pt" >&nbsp Preoperative radiotherapy</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="h0" disabled="true" onClick = "document.form.h0.checked=true;document.form.h1.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" font color="Gray" id="PRN" style="font-size:12pt" >No</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="h1" disabled="true" onClick = "document.form.h0.checked=false;document.form.h1.checked=true;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" font color="Gray" id="PRY" style="font-size:12pt" >Yes</td>
<td valign="center" align="right" width="20"></td>
<td valign="center" align="center" width="80"></td>
<td width="20"> </td>
<td width="80"> </td>
<td width="20"> </td>
<td width="80"> </td>
</tr>

</tr>
<tr bgcolor="#f3f3f1" height="50">
<td valign="center" align="left" width="300">
<font face="verdana" style="font-size:12pt" >&nbsp No. examined lymphnodes</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="e0" checked onClick = "document.form.e0.checked=true;document.form.e1.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt" >12+</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="e1" onClick = "document.form.e0.checked=false;document.form.e1.checked=true;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt" >0-11</td>
<td valign="center" align="right" width="20"></td>
<td valign="center" align="center" width="80"></td>
<td width="20"> </td>
<td width="80"> </td>
<td width="20"> </td>
<td width="80"> </td>
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<tr height="50">
<td valign="center" align="left" width="300">
<font face="verdana" style="font-size:12pt" >&nbsp Adjuvant chemotherapy</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="i0" checked onClick = "document.form.i0.checked=true;document.form.i1.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt" >No</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="i1" onClick = "document.form.i0.checked=false;document.form.i1.checked=true;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt" >Yes</td>
<td valign="center" align="right" width="20"></td>
<td valign="center" align="center" width="80"></td>
<td width="20"> </td>
<td width="80"> </td>
<td width="20"> </td>
<td width="80"> </td>
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<tr bgcolor="#f3f3f1" height="50">
<td valign="center" align="left" width="300">
<font face="verdana" style="font-size:12pt"  id="MT">&nbsp Mucinous tumour</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="mt0" checked onClick = "document.form.mt0.checked=true;document.form.mt1.checked=false;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt"  id="MTno">No</td>
<td valign="center" align="center" width="20">
<input type="checkbox" name="mt1" onClick = "document.form.mt0.checked=false;document.form.mt1.checked=true;Calculate()"></td>
<td valign="center" align="left" width="80"><font face="verdana" style="font-size:12pt"  id="MTyes">Yes</td>
<td valign="center" align="right" width="20"></td>
<td valign="center" align="center" width="80"></td>
<td width="20"> </td>
<td width="80"> </td>
<td width="20"> </td>
<td width="80"> </td>
</tr>

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Segelman J, Akre O, Gustafsson UO, Bottai M, Martling A. Individualized prediction of risk of metachronous peritoneal carcinomatosis from colorectal cancer. Colorectal Disease. 2014 May;16(5):359-67. <a style="font-family:verdana,sans-serif; font-size:10pt"href="http://onlinelibrary.wiley.com/doi/10.1111/codi.12552/abstract;jsessionid=24C1DA8B6DC6624E7FE93EB0DEE5B53A.f03t03" target=_blank>doi: 10.1111/codi.12552</a>
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Segelman J, Akre O, Gustafsson UO, Bottai M, Martling A. External validation of models predicting the individual risk of metachronous peritoneal carcinomatosis from colon and rectal cancer. Colorectal Dis. 2016 Apr;18(4):378-85. <a style="font-family:verdana,sans-serif; font-size:10pt" href="https://www.ncbi.nlm.nih.gov/pubmed/26588669" target=_blank>doi: 10.1111/codi.13219.</a>

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