<html>
<head>
<title>Unit of Biostatistics - Karolinska Institutet</title>
<META NAME="Keywords" CONTENT="Unit Biostatistics Software Command Publications Presentations stata programming imm karolinska imm institute environmental">

<!-- Global site tag (gtag.js) - Google Analytics -->
<script async src="https://www.googletagmanager.com/gtag/js?id=UA-111023441-1"></script>
<script>
  window.dataLayer = window.dataLayer || [];
  function gtag(){dataLayer.push(arguments);}
  gtag('js', new Date());

  gtag('config', 'UA-111023441-1');
</script>



<link rel="shortcut icon" href="http://www.imm.ki.se/biostatistics/images/header.ico" type="image/x-icon" />

<style>
table{
	background-color: "white";
       	font-family:verdana, "sans-serif";
	font-size:12pt;
	color:black;
	padding: 0px;
	border: 0px;
	border-spacing:0;
	border-collapse:collapse;
	width:600px;
	}
tr{
	height:50px;
	}
td {
	vertical-align:center
	text-align:left;
	}
td#td1{
	text-align:center;
	width:125px;
	}
td#td4{
	width:400px;
	}
td#td2{
	width:25px;
	text-align:left;
	}
td#td3{
	width:50px;
	}
input#input1[type="text"]{
	text-align:center;
	font-size:16px;
	width:50px;
	overflow:hidden;
	border:solid 0px #000000;
	}
input#PSA[type="text"]{
	text-align:center;
	font-size:16px;
	width:50px;
	}
input#PosBio[type="text"]{
	text-align:center;
	font-size:16px;
	width:50px;
	}
input#NegBio[type="text"]{
	text-align:center;
	font-size:16px;
	width:50px;
	}
input#input3[type="checked"]{
	text-align:left;
	font-size:16px;
	width:50px;
	}
A:LINK{
	font-family:  verdana;
	text-decoration: none;
	color: #000000;
	  }

A:VISITED {
	font-family:  verdana;
	text-decoration: none;
	color: #000000;
	}

A:HOVER{
	color: #c0c0c0;
	font-family:  verdana;
	text-decoration: none;
      }
</style>

<SCRIPT LANGUAGE="JavaScript">

function Calculate(){

	if (eval(document.getElementById('PSA').value) > 20) document.form.PSA.value = "20"
	if (eval(document.getElementById('PSA').value) < 0) document.form.PSA.value = "0"

	temp =  Math.log(eval(document.getElementById('PSA').value))/Math.log(2)*0.43+
		eval(document.getElementById('PosBio').value)*0.08-
		eval(document.getElementById('NegBio').value)*0.06+
		eval(document.form.T21.checked)*0.22+
		eval(document.form.PG1.checked)*0.88+
		eval(document.form.SG1.checked)*0.46+
		eval(document.form.T20.checked)*0+
		eval(document.form.PG0.checked)*0+
		eval(document.form.SG0.checked)*0

	temp1 = Math.exp(temp)


	document.form.R1.value = Math.round(Math.pow(0.9932962,temp1)*100)+"%"
	document.form.R2.value = Math.round(Math.pow(0.9824007,temp1)*100)+"%"
	document.form.R3.value = Math.round(Math.pow(0.9733992,temp1)*100)+"%"
	document.form.R5.value = Math.round(Math.pow(0.9590204,temp1)*100)+"%"

	if (isNaN(temp)){
		document.form.R1.value = ""
		document.form.R2.value = ""
		document.form.R3.value = ""
		document.form.R5.value = ""
	}
  
}


</script>


</head>

<body bgcolor="white">

<form name="form">
<center>

<table >
	<tr>
		<td colspan=4 align=right>
		<a href="index.html"><img src="swedishflag.gif" border=0 height=13pt> Swedish</a>
		</td>
	</tr>
	<tr bgcolor="#f3f3f1">
		<td align="center" style="padding: 10px 0px 10px 0px;"><font size=4>
		<b>Progression-free probability after radical prostatectomy for localized prostate cancer</b></font>
		</td>
	</tr>
</table>


<br><br>

<hr width="500" color="silver">
<table style="width:500px">
	<tr style="height:0px">
		<td id="td1">1 year</td>
		<td id="td1">2 years</td>
		<td id="td1">3 years</td>
		<td id="td1">5 years</td>
	<tr style="height:0px">
		
<td id="td1">
<input id="input1" type="text" readonly='readonly' name="R1" value="98%"></td>
		
<td id="td1">
<input id="input1" type="text" readonly='readonly' name="R2" value="95%"></td>
		
<td id="td1">
<input id="input1" type="text" readonly='readonly' name="R3" value="93%"></td>
		
<td id="td1">
<input id="input1" type="text" readonly='readonly' name="R5" value="89%"></td>
	</tr>
</table>
<hr width="500" color="silver">

<br><br>

<table id="t1">
	<tr bgcolor="#f3f3f1">
		<td id="td4">&nbsp PSA level</td>
		<td id="td2" colspan="2"><input id="PSA" type="text" value='7.5' onchange="Calculate()"></td>
		<td id="td2"></td><td id="td3"> </td>
	</tr>

	<tr>
		<td id="td4">&nbsp Number of positive biopsy cores</td>
		<td id="td2" colspan="2"><input id="PosBio" type="text" value='1' onchange="Calculate()"></td>
		<td id="td2"></td><td id="td3"> </td>
	</tr>

	<tr bgcolor="#f3f3f1">
		<td id="td4">&nbsp Number of negative biopsy cores</td>
		<td id="td2" colspan="2"><input id="NegBio" type="text" value='5' onchange="Calculate()"></td>
		<td id="td2"></td><td id="td3"> </td>
	</tr>
	<tr>
		<td id="td4">&nbsp T stage</td>
		<td id="td2"><input id="input3" type="checkbox" name="T20" checked onClick="document.form.T20.checked=true;document.form.T21.checked=false;Calculate()">
</td>
		<td id="td3">T1
</td>
		<td id="td2"><input id="input3" type="checkbox" name="T21" onClick="document.form.T20.checked=false;document.form.T21.checked=true;Calculate()"></td>
		<td id="td3">T2
</td>
	</tr>

	<tr bgcolor="#f3f3f1">
		<td id="td4">&nbsp Primary Gleason grade</td>
		<td id="td2"><input id="input3" type="checkbox" name="PG0" checked onClick = "document.form.PG0.checked=true;document.form.PG1.checked=false;Calculate()"></td>
		<td id="td3">2-3</td>
		<td id="td2"><input id="input3" type="checkbox" name="PG1" onClick = "document.form.PG0.checked=false;document.form.PG1.checked=true;Calculate()"></td>
		<td id="td3" colspan="2">3-4</td>

	
</tr>

	<tr>
		<td id="td4">&nbsp Secondary Gleason grade</td>
		<td id="td2"><input id="input3" type="checkbox" name="SG0" checked onClick = "document.form.SG0.checked=true;document.form.SG1.checked=false;Calculate()"></td>
		<td id="td3">2-3</td>
		<td id="td2"><input id="input3" type="checkbox" name="SG1" onClick = "document.form.SG0.checked=false;document.form.SG1.checked=true;Calculate()"></td>
		<td id="td3" colspan="2">3-4</td>

	
</tr>

	<tr>
		<td id="td4" colspan=5>
		<br><hr color="silver">
		<font size=2>The calculator was developed using data from a 5-year follow-up in NPCR with the following inclusion criteria: age less than 70 years, clinical T stage T1 or T2, no lymphonode metastases N0/Nx, no bone metastases M0/Mx, and PSA levels less than 20 ng/mL</font>
		</td>
	
</tr>


</table>

</body>
</html>